Title : Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity.

Pub. Date : 2009 Jun

PMID : 18754103






1 Functional Relationships(s)
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1 To investigate any similarities in the inhibition of CYP2E1 by quinacrine and disulfiram, molecular modeling techniques were adopted and revealed that quinacrine molecule anchors inside the same binding pocket of the protein where disulfiram is also attached. Disulfiram cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus