Title : [Regulatory effect of resveratrol on JAK1/STAT3 signal transduction pathway in leukemia].

Pub. Date : 2008 Aug

PMID : 18718058






4 Functional Relationships(s)
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1 [Regulatory effect of resveratrol on JAK1/STAT3 signal transduction pathway in leukemia]. Resveratrol signal transducer and activator of transcription 3 Mus musculus
2 The results indicated that resveratrol could significantly inhibit the JAK1/STAT3 signal transduction pathway, down-regulate expressions of pJAK1 and pSTAT3 and reduce the phosphorylation of JAK1 and STAT3 in a dose-and time-dependent manner. Resveratrol signal transducer and activator of transcription 3 Mus musculus
3 The results indicated that resveratrol could significantly inhibit the JAK1/STAT3 signal transduction pathway, down-regulate expressions of pJAK1 and pSTAT3 and reduce the phosphorylation of JAK1 and STAT3 in a dose-and time-dependent manner. Resveratrol signal transducer and activator of transcription 3 Mus musculus
4 It is concluded that the resveratrol can regulate signal transduction pathway and reduce the activation of JAK1/STAT3 tyrosine phosphorylation significantly, and therefore resveratrol shows chemotherapeutic potential to leukaemia. Resveratrol signal transducer and activator of transcription 3 Mus musculus