Title : The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation.

Pub. Date : 2008 Nov

PMID : 18705646






1 Functional Relationships(s)
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1 Upon activation, the MT1 receptor specifically couples to the G(alphai2), G(alphai3), G(alphaq), and G(alphall) proteins, and via activation of G(alphai2) proteins, melatonin suppresses forskolin-induced 3",5"-cyclic adenosine monophosphate production, while melatonin activation of G(alphaq), is able to inhibit phospholipid hydrolysis and ATP"s induction of inositol triphosphate production in MCF-7 breast cancer cells. Inositol triphosphate metallothionein 1I, pseudogene Homo sapiens