Title : Drug-resistant AML cells and primary AML specimens are killed by 111In-anti-CD33 monoclonal antibodies modified with nuclear localizing peptide sequences.

Pub. Date : 2008 Sep

PMID : 18703602






1 Functional Relationships(s)
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1 RESULTS: The (111)In-labeled anti-CD33 monoclonal antibodies HuM195 and M195 modified with NLS were efficiently routed to the nucleus of HL-60 cells and their mitoxantrone-resistant clone after CD33-mediated internalization. Mitoxantrone CD33 molecule Homo sapiens