Title : Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5.

Pub. Date : 2008 Oct 1

PMID : 18703135






2 Functional Relationships(s)
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1 Cd-induced ROS was also linked to the activation of caspase-3. Cadmium caspase 3 Homo sapiens
2 Pretreatment with inhibitors of JNK (SP600125) and Erk1/2 (U0126) partially blocked Cd-induced cleavage of caspase-3 and prevented cell death. Cadmium caspase 3 Homo sapiens