Pub. Date : 2008 Aug 15
PMID : 18701496
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of TRAIL by the HDAC inhibitor MS275 can be enhanced by Adriamycin. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 2 | Using different reporter constructs in conjunction with transcription activity assays and chromatin immunoprecipitation assays, we provide evidence that the transcription factor Sp1 is responsible for TRAIL induction by MS275 alone or in combination with Adriamycin. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 3 | Down-regulation of TRAIL by small interfering RNA silencing decreased MS275-mediated Adriamycin-induced caspase activation and apoptosis, thus conferring Adriamycin resistance. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 4 | Down-regulation of TRAIL by small interfering RNA silencing decreased MS275-mediated Adriamycin-induced caspase activation and apoptosis, thus conferring Adriamycin resistance. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 5 | Taken together, our results indicate that induction of TRAIL by the combined treatments with MS275 and Adriamycin is mediated by Sp1 and suggest that transcription factor Sp1 is an important target for the development of novel anticancer agents. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |