Title : Regulation of maternal ACTH in ovine pregnancy: does progesterone play a role?

Pub. Date : 2008 Oct

PMID : 18697912






3 Functional Relationships(s)
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1 In adrenalectomized ewes chronically replaced to 0.35 mg x kg(-1) x day(-1) cortisol, plasma ACTH concentrations were decreased significantly in the nonpregnant progesterone-treated ewes compared with the ovariectomized nonpregnant ewes. Progesterone proopiomelanocortin Homo sapiens
2 With 0.5 mg x kg(-1) x day(-1) cortisol, plasma ACTH levels were greater in pregnant ewes than in nonpregnant ewes with or without progesterone. Progesterone proopiomelanocortin Homo sapiens
3 We conclude that increased progesterone does not alter the feedback relation of cortisol to ACTH, but may modulate ACTH indirectly through plasma volume. Progesterone proopiomelanocortin Homo sapiens