Pub. Date : 2008 Oct 10
PMID : 18687691
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. | Isoflavones | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We found that isoflavone inhibited the phosphorylation of Akt and FOXO3a, regulated the phosphorylation of Src, and increased the expression of GSK-3beta, leading to the down-regulation of AR and its target gene PSA. | Isoflavones | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results suggest that isoflavone-induced inhibition of cell proliferation and induction of apoptosis are partly mediated through the regulation of the Akt/FOXO3a/GSK-3beta/AR signaling network. | Isoflavones | AKT serine/threonine kinase 1 | Homo sapiens |