Title : Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine.

Pub. Date : 2008 Sep 15

PMID : 18680729






1 Functional Relationships(s)
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1 This study provides evidence that in a scintillation proximity assay levocabastine (IC(50) 406 microM), but not the first-generation antihistamine chlorpheniramine, displaced (125)I-FN binding to human integrin alpha(4)beta(1) and, in flow cytometry analysis, levocabastine antagonized the binding of a primary antibody to integrin alpha(4) expressed on the Jurkat cell surface. levocabastine integrin subunit alpha 4 Homo sapiens