Title : Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E.

Pub. Date : 2008 Aug 15

PMID : 18656365






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1 We report here the design and synthesis of N-heterocycle-containing analogues of alpha-tocopherol that act as inhibitors of Cyp4F2, the key monooxygenase responsible for omega-hydroxylation of the side chain of tocols. alpha-Tocopherol cytochrome P450 family 4 subfamily F member 2 Homo sapiens