Title : Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells.

Pub. Date : 2008 Nov

PMID : 18654741






1 Functional Relationships(s)
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1 CONCLUSION: The involvement of secretory transporters P-gp, MRP2 and BCRP, particularly for belotecan, as well as a low passive permeability, appears to be responsible for the low bioavailability of belotecan and topotecan. Topotecan PGP Canis lupus familiaris