Title : Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis.

Pub. Date : 2008 Aug 20

PMID : 18652829






3 Functional Relationships(s)
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1 A peptide constrained to a conformation of second extracellular loop of human prostaglandin-E(2) (PGE(2)) receptor subtype3 (hEP3) was synthesized. Prostaglandins E prostaglandin E receptor 3 Homo sapiens
2 This study found that the non-conserved S211 and R214 of the hEP3 are involved in PGE(2) recognition, and implied that the corresponding residues in other subtype receptors could be important to distinguish the different configurations of PGE(2) ligand recognition sites. Prostaglandins E prostaglandin E receptor 3 Homo sapiens
3 This study found that the non-conserved S211 and R214 of the hEP3 are involved in PGE(2) recognition, and implied that the corresponding residues in other subtype receptors could be important to distinguish the different configurations of PGE(2) ligand recognition sites. Prostaglandins E prostaglandin E receptor 3 Homo sapiens