Pub. Date : 2008 Nov
PMID : 18648086
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | administration (50 mg/kg) of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) increased mRNA expression of Cyp2B10 (20-fold), 3A11 (two-fold), and 4A14 (32-fold), but not Cyp1A1/2 in mouse livers. | perfluorodecanoic acid | cytochrome P450, family 2, subfamily b, polypeptide 10 | Mus musculus |
| 2 | administration (50 mg/kg) of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) increased mRNA expression of Cyp2B10 (20-fold), 3A11 (two-fold), and 4A14 (32-fold), but not Cyp1A1/2 in mouse livers. | perfluorodecanoic acid | cytochrome P450, family 2, subfamily b, polypeptide 10 | Mus musculus |
| 3 | PFDA and PFOA also markedly increased protein expression of Cyp2B (50-fold) and 4A (10-fold). | perfluorodecanoic acid | cytochrome P450, family 2, subfamily b, polypeptide 10 | Mus musculus |
| 4 | PFDA increased Cyp4A14 mRNA expression at relatively low doses (0.5 mg/kg), but increased Cyp2B10 mRNA expression only at high doses (> 20 mg/kg). | perfluorodecanoic acid | cytochrome P450, family 2, subfamily b, polypeptide 10 | Mus musculus |
| 5 | PFDA increased Cyp2B10 mRNA expression in WT mice, but not in CAR-null mice. | perfluorodecanoic acid | cytochrome P450, family 2, subfamily b, polypeptide 10 | Mus musculus |