Pub. Date : 2008 Sep
PMID : 18645049
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the balance of NO and superoxide produced by this enzyme. | Superoxides | GTP cyclohydrolase 1 | Mus musculus |
| 2 | GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the balance of NO and superoxide produced by this enzyme. | Superoxides | GTP cyclohydrolase 1 | Mus musculus |
| 3 | BH4 reduction induced by GTPCH1 siRNA injection was associated with increased aortic levels of superoxide, 3-nitrotyrosine, and adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1), as well as a significantly elevated systolic, diastolic, and mean BP in C57BL6 mice. | Superoxides | GTP cyclohydrolase 1 | Mus musculus |