Title : Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.

Pub. Date : 2008 Jul

PMID : 18644996






1 Functional Relationships(s)
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1 In vivo, camptothecin and B-5354c alone display a limited effect on tumor growth in PC-3 cells, whereas in combination there is a synergy of effect on tumor size with a significant increase in the ceramide to S1P sphingolipid ratio. Sphingolipids membrane bound transcription factor peptidase, site 1 Homo sapiens