Pub. Date : 2008 Aug
PMID : 18635526
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The tobacco component nicotine increases the transcription of the survivin gene in non-small cell lung cancer cells. | Nicotine | baculoviral IAP repeat-containing 5 | Mus musculus |
| 2 | We investigated the effects of the tobacco components nicotine and its related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on survivin expression in normal human bronchial epithelial (NHBE) cells and examined the role of survivin in the malignant transformation of normal human bronchial epithelial (HBE) cells induced by these components. | Nicotine | baculoviral IAP repeat-containing 5 | Mus musculus |
| 3 | Nicotine and NNK increased survivin mRNA and protein expression levels in primary cultured NHBE cells and immortalized HBE cells. | Nicotine | baculoviral IAP repeat-containing 5 | Mus musculus |
| 4 | Nicotine and NNK stimulated the Akt-mammalian target of rapamycin (mTOR) pathway in NHBE cells, leading to increased de novo synthesis of survivin protein. | Nicotine | baculoviral IAP repeat-containing 5 | Mus musculus |
| 5 | These findings suggest that NNK and nicotine induce survivin protein synthesis in NHBE cells by activating the Akt-mTOR pathway and thus blockade of the pathway effectively inhibits the tobacco-induced malignant transformation of HBE cells. | Nicotine | baculoviral IAP repeat-containing 5 | Mus musculus |