Title : Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

Pub. Date : 2008 Jul 15

PMID : 18628471






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CDDO-Me inhibited constitutive STAT3 phosphorylation and the degradation of IKBalpha in ER-negative breast cancer cells, whereas 268 blocked IKBalpha degradation and the release of interleukin-6 in RAW264.7 macrophage-like cells, inhibited the ability of endothelial cells to organize into networks, and blocked angiogenesis in vivo. bardoxolone methyl signal transducer and activator of transcription 3 Mus musculus