Title : Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.

Pub. Date : 2010 Apr

PMID : 18597895






1 Functional Relationships(s)
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1 Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation. Oxysterols nuclear receptor subfamily 1 group H member 3 Homo sapiens