Pub. Date : 2009 May 15
PMID : 18597869
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. | Metformin | tumor necrosis factor | Homo sapiens |
| 2 | The effects of metformin on TNF-alpha-induced IL-6 production were investigated. | Metformin | tumor necrosis factor | Homo sapiens |
| 3 | Pre-treatment with metformin (100-1000 micromol/L) also inhibited TNF-alpha-induced IL-6 production, phosphorylation of IkappaB kinase (IKK) alpha/beta and IkappaB-alpha degradation. | Metformin | tumor necrosis factor | Homo sapiens |
| 4 | Metformin increased phosphorylation of AMP-activated kinase (AMPK) but wortmannin, a PI3K inhibitor, negated its effects on AMPK phosphorylation and TNF-alpha-induced IkappaB-alpha degradation. | Metformin | tumor necrosis factor | Homo sapiens |
| 5 | Transfection of siRNA against alpha1-AMPK eradicated the inhibitory effects of metformin on TNF-alpha-induced IL-6, implying the essential role of AMPK. | Metformin | tumor necrosis factor | Homo sapiens |
| 6 | CONCLUSIONS: Metformin had anti-inflammatory effects on endothelial cells and inhibited TNF-alpha-induced IKKalpha/beta phosphorylation, IkappaB-alpha degradation and IL-6 production in HUVEC. | Metformin | tumor necrosis factor | Homo sapiens |