Title : Activation of notch signaling in a xenograft model of brain metastasis.

Pub. Date : 2008 Jul 1

PMID : 18593982






2 Functional Relationships(s)
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1 Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1. dapt notch receptor 1 Homo sapiens
2 Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1. dapt notch receptor 1 Homo sapiens