Title : Molecular design based on receptor-independent pharmacophore: application to estrogen receptor ligands.

Pub. Date : 2008 Jul

PMID : 18591792






1 Functional Relationships(s)
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1 The studies show (R=0.945, RMSD=2.186, Deltacost=677.354) the importance of hydrogen bond acceptors in the aromatic rings and a planner hydrophobic region in the molecular architecture along with critical geometrical distance between features are effectively crucial for binding with ER. Hydrogen estrogen receptor 1 Homo sapiens