Title : Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.

Pub. Date : 2008 Aug 20

PMID : 18573248






3 Functional Relationships(s)
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1 The administration of intrathecal nicotinic acetylcholine receptor agonists reduced mechanical paw pressure thresholds with a potency of epibatidine=A-85380>>nicotine>choline in the normal rat. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 The antinociceptive response to intrathecal nicotine was blocked with the alpha7 and alpha9alpha10-selective nicotinic acetylcholine receptor antagonist, MLA, and the alphabeta heteromeric nicotinic acetylcholine receptor antagonist, DHbetaE. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
3 The antinociceptive response to intrathecal nicotine was blocked with the alpha7 and alpha9alpha10-selective nicotinic acetylcholine receptor antagonist, MLA, and the alphabeta heteromeric nicotinic acetylcholine receptor antagonist, DHbetaE. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus