Pub. Date : 2008 Oct
PMID : 18567737
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. | Resveratrol | protein tyrosine phosphatase non-receptor type 1 | Homo sapiens |
| 2 | Interestingly, resveratrol increased the activity of protein tyrosine phosphatase PTP1B, which dephosphorylates PDGF-stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and Erk1/2 kinase activity. | Resveratrol | protein tyrosine phosphatase non-receptor type 1 | Homo sapiens |
| 3 | These results for the first time provide evidence that the stilbene resveratrol targets PTP1B to inhibit PDGFR mitogenic signaling. | Resveratrol | protein tyrosine phosphatase non-receptor type 1 | Homo sapiens |