Title : Evidence for the formation of a covalent thiosulfinate intermediate with peroxiredoxin in the catalytic mechanism of sulfiredoxin.

Pub. Date : 2008 Aug 15

PMID : 18552404






1 Functional Relationships(s)
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1 Coordination of these functions depends on the sulfinylation of the catalytic Cys, a modification reversed by ATP-dependent sulfiredoxin, which specifically reduces the sulfinic acid group of overoxidized 2-Cys peroxiredoxins into a sulfenic acid. 2-cys peroxiredoxins sulfiredoxin Saccharomyces cerevisiae S288C