Title : The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex.

Pub. Date : 2008 Aug 1

PMID : 18522938






3 Functional Relationships(s)
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1 Here we show that superoxide formation at the ubiquinol oxidation center of the membrane-bound or purified cytochrome bc(1) complex is stimulated by the presence of oxidized ubiquinone indicating that in a reverse reaction the electron is transferred onto oxygen from reduced cytochrome b(L) via ubiquinone rather than during the forward ubiquinone cycle reaction. Ubiquinone mitochondrially encoded cytochrome b Homo sapiens
2 Here we show that superoxide formation at the ubiquinol oxidation center of the membrane-bound or purified cytochrome bc(1) complex is stimulated by the presence of oxidized ubiquinone indicating that in a reverse reaction the electron is transferred onto oxygen from reduced cytochrome b(L) via ubiquinone rather than during the forward ubiquinone cycle reaction. Ubiquinone mitochondrially encoded cytochrome b Homo sapiens
3 Here we show that superoxide formation at the ubiquinol oxidation center of the membrane-bound or purified cytochrome bc(1) complex is stimulated by the presence of oxidized ubiquinone indicating that in a reverse reaction the electron is transferred onto oxygen from reduced cytochrome b(L) via ubiquinone rather than during the forward ubiquinone cycle reaction. Ubiquinone mitochondrially encoded cytochrome b Homo sapiens