Title : Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.

Pub. Date : 2008 Jun 1

PMID : 18519703






2 Functional Relationships(s)
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1 Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. pregna-4,17-diene-3,16-dione protein tyrosine phosphatase non-receptor type 6 Homo sapiens
2 Indeed, we found that GS induced the expression of both the protein and mRNA for tyrosine protein phosphatase SHP-1 that was not due to demethylation of the SHP-1 promoter previously implicated in the epigenetic silencing of SHP-1. pregna-4,17-diene-3,16-dione protein tyrosine phosphatase non-receptor type 6 Homo sapiens