Title : Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.

Pub. Date : 2008

PMID : 18515984






2 Functional Relationships(s)
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1 The expression of PSA, KLK10 and KLK11 was repressed by the MEK1/2 inhibitor U0126 and the PI3K inhibitor Wortmannin in the presence of the hormone, thus implicating the RAS/MEK/ERK and PI3K/AKT signaling pathways in regulating hormone-dependent KLK gene activation. U 0126 kallikrein related peptidase 10 Homo sapiens
2 The expression of PSA, KLK10 and KLK11 was repressed by the MEK1/2 inhibitor U0126 and the PI3K inhibitor Wortmannin in the presence of the hormone, thus implicating the RAS/MEK/ERK and PI3K/AKT signaling pathways in regulating hormone-dependent KLK gene activation. U 0126 kallikrein related peptidase 10 Homo sapiens