Title : Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.

Pub. Date : 2008 Sep 19

PMID : 18515365






1 Functional Relationships(s)
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Protein Name
Organism
1 IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interleukin 1 beta Homo sapiens