Title : Granulocyte colony stimulating factor increases drug resistance of leukaemic blast cells to daunorubicin.

Pub. Date : 2008 Sep

PMID : 18493867






4 Functional Relationships(s)
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1 Granulocyte colony stimulating factor increases drug resistance of leukaemic blast cells to daunorubicin. Daunorubicin colony stimulating factor 3 Homo sapiens
2 In this study we investigated how G-CSF might influence the sensitivity of leukemic cells to daunorubicin induced cell death using MTT assay, flow cytometry and Western blot analysis. Daunorubicin colony stimulating factor 3 Homo sapiens
3 After pretreatment of KG-1 leukaemic cells with G-CSF a moderate increase in the resistance of these cells to daunorubicin could be observed. Daunorubicin colony stimulating factor 3 Homo sapiens
4 In addition, adjuvant treatment of AML patients with G-CSF in order to prevent neutropenia, or its use in priming regimens might result resistance to daunorubicin. Daunorubicin colony stimulating factor 3 Homo sapiens