Title : Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: effects on distribution of a model organic cation, tetraethylammonium.

Pub. Date : 2009 Feb

PMID : 18484100






4 Functional Relationships(s)
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1 The effect of reduced Oct2 expression on the distribution of a model OC, tetraethylammonium (TEA), in various rat tissues including kidney cortex and kidney medulla was investigated during steady state plasma TEA concentrations. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
2 The effect of reduced Oct2 expression on the distribution of a model OC, tetraethylammonium (TEA), in various rat tissues including kidney cortex and kidney medulla was investigated during steady state plasma TEA concentrations. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
3 These results indicate that, in a rat model of ARF, reduced Oct2 expression in the kidney medulla results in decreased distribution of TEA to the kidney medulla, thereby reducing renal clearance of TEA in UN-ARF rats. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
4 These results indicate that, in a rat model of ARF, reduced Oct2 expression in the kidney medulla results in decreased distribution of TEA to the kidney medulla, thereby reducing renal clearance of TEA in UN-ARF rats. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus