Title : Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.

Pub. Date : 2008 May 15

PMID : 18483253






1 Functional Relationships(s)
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1 We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. pab1620 homeodomain interacting protein kinase 2 Homo sapiens