Pub. Date : 2008 Dec
PMID : 18482832
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to analyse the effect of chronic administration (13 weeks) of DHEA (5 g/kg diet) to old female rats fed on a high-fat diet on body weight and adiposity, and concretely on the expression of the adipokines related to obesity and insulin resistance, such as leptin, adiponectin and resistin. | Dehydroepiandrosterone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |
| 2 | DHEA treatment induced a decrease in body weight, adipose tissue mass and serum insulin, adiponectin and leptin levels. | Dehydroepiandrosterone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |
| 3 | Adiponectin mRNA expression in visceral fat depots decreased with aging, but this reduction was attenuated by DHEA treatment. | Dehydroepiandrosterone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |
| 4 | In conclusion, DHEA treatment decreases body weight and adiposity in old female rats fed a high-fat diet, leading to an improvement of the HOMA index for insulin sensitivity, with decreasing circulating insulin levels, and preventing the age-associated decline of visceral-adipose adiponectin expression. | Dehydroepiandrosterone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |