Title : Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.

Pub. Date : 2008 Aug

PMID : 18480186






2 Functional Relationships(s)
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1 Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. curcuminoids UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens
2 All three curcuminoids had similar effects on CYP3A, UGT, and SULT activity, but demethoxycurcumin (IC(50) = 8.8 +/- 1.2 microM) was more active against CYP2C9 than either curcumin or bisdemethoxycurcumin (IC(50) > 50 microM). curcuminoids UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens