Pub. Date : 2008 Aug
PMID : 18477628
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was possible that the suppression of GRP78 expression by nicotine was achieved through the suppression of the Ire1-XBP1 and/or ATF6 pathways. | Nicotine | X-box binding protein 1 | Rattus norvegicus |
| 2 | We observed that nicotine suppressed the Tm-induced, but not Tg-induced, splicing of XBP1 mRNA, and also suppressed the Tm-induced, but not Tg-induced, production of cleaved ATF6 in PC12 cells. | Nicotine | X-box binding protein 1 | Rattus norvegicus |
| 3 | These results indicate that the suppression of Ire1-XBP1 and ATF6 pathways contributes to the suppression of GRP78 expression by nicotine in Tm-treated PC12 cells, suggesting that nicotine suppresses a common step upstream of both the Ire1-XBP1 and ATF6 pathways which are required for the expression of GRP78 during Tm-induced ER stress. | Nicotine | X-box binding protein 1 | Rattus norvegicus |
| 4 | These results indicate that the suppression of Ire1-XBP1 and ATF6 pathways contributes to the suppression of GRP78 expression by nicotine in Tm-treated PC12 cells, suggesting that nicotine suppresses a common step upstream of both the Ire1-XBP1 and ATF6 pathways which are required for the expression of GRP78 during Tm-induced ER stress. | Nicotine | X-box binding protein 1 | Rattus norvegicus |
| 5 | These results indicate that the suppression of Ire1-XBP1 and ATF6 pathways contributes to the suppression of GRP78 expression by nicotine in Tm-treated PC12 cells, suggesting that nicotine suppresses a common step upstream of both the Ire1-XBP1 and ATF6 pathways which are required for the expression of GRP78 during Tm-induced ER stress. | Nicotine | X-box binding protein 1 | Rattus norvegicus |