Title : Carbohydrate modifications transform human chorionic gonadotropin into a potent stimulator of adenosine 3',5'-monophosphate and growth responses in FRTL-5 thyroid cells.

Pub. Date : 1991 Feb

PMID : 1846577






3 Functional Relationships(s)
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1 To delineate the role of carbohydrate moiety in the expression of in vitro thyrotropic activity of hCG, its variants that lacked sialic acid residues or the entire carbohydrate moiety on one or both subunits were prepared. Carbohydrates chorionic gonadotropin subunit beta 5 Homo sapiens
2 Results of these studies strongly suggest that the optimal expression of in vitro thyrotropic activity of hCG variants in FRTL-5 cells may require an alpha-subunit, with intact carbohydrate, in combination with the deglycosylated beta-subunit. Carbohydrates chorionic gonadotropin subunit beta 5 Homo sapiens
3 Further, they demonstrate that modification of the hCG carbohydrate moiety alone can transform it from a weak agonist to a potent stimulator of in vitro thyrotropic bioactivity. Carbohydrates chorionic gonadotropin subunit beta 5 Homo sapiens