Title : T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional mu-opioid receptors.

Pub. Date : 2008 Aug

PMID : 18463202






1 Functional Relationships(s)
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1 Furthermore, we demonstrated that the induction of interleukin-2 mRNA and protein in activated T cells was inhibited by morphine in cells, in which mu-opioid receptors had been induced by CD3/28 monoclonal antibodies (mAbs), and that this effect was blocked by the mu-opioid receptor-specific antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2). Tyrosine interleukin 2 Homo sapiens