Pub. Date : 2008
PMID : 18462615
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leptin inhibits basal but not gonadotrophin-stimulated testosterone production in the immature mouse and sheep testis. | Testosterone | leptin | Mus musculus |
| 2 | The mechanisms whereby leptin regulates testosterone secretion are complex and are likely to involve actions at different levels of the hypothalamus-pituitary-gonadal axis. | Testosterone | leptin | Mus musculus |
| 3 | Testosterone data from testicular slice and Leydig cells of immature and adult mice testes demonstrated that the action of leptin in the regulation of steroidogenesis appears to be dependent on the developmental stage of the testis. | Testosterone | leptin | Mus musculus |
| 4 | Leptin biphasically modulates basal testosterone production in immature testicular slice cultures: at relatively low concentrations (6.25-12.5 ng mL(-1)) leptin exerts a significant inhibitory effect, but has less of an effect at very low (1.25 ng mL(-1)) or high concentrations (25 ng mL(-1)). | Testosterone | leptin | Mus musculus |
| 5 | Leptin biphasically modulates basal testosterone production in immature testicular slice cultures: at relatively low concentrations (6.25-12.5 ng mL(-1)) leptin exerts a significant inhibitory effect, but has less of an effect at very low (1.25 ng mL(-1)) or high concentrations (25 ng mL(-1)). | Testosterone | leptin | Mus musculus |
| 6 | Leptin (1.56-25 ng mL(-1)) significantly inhibited basal testosterone production in the testis from birth to Day 21, but had no effect on Day 27 or older testes. | Testosterone | leptin | Mus musculus |
| 7 | This does not exclude the possibility of a non-competitive mechanism of interaction between leptin and luteinising hormone to regulate testosterone production. | Testosterone | leptin | Mus musculus |
| 8 | The physiological significance and mechanism of leptin regulation of basal testosterone production are not known; further studies are required to elucidate these important issues. | Testosterone | leptin | Mus musculus |