Pub. Date : 2008 Jun
PMID : 18459160
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 2 | In the present study we explored a relationship between H2AX phosphorylation and activation of checkpoint kinase 2 (Chk2) in human lung carcinoma A549 cells treated with TPT or with MXT. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 3 | In the present study we explored a relationship between H2AX phosphorylation and activation of checkpoint kinase 2 (Chk2) in human lung carcinoma A549 cells treated with TPT or with MXT. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 4 | Upon treatment with TPT or MTX, the activated Chk2 presented itself in form of either minute or large IF foci in the cell"s nucleoplasm. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 5 | TPT or MXT induced Chk2 activation occurred at a distinctly slower pace, peaking at 4 h. While TPT-induced H2AX phosphorylation and Chk2 activation were maximal in S-phase cells, Chk2 activation was also much pronounced in G(2)M cells; the least affected by TPT were G(1) cells. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 6 | TPT or MXT induced Chk2 activation occurred at a distinctly slower pace, peaking at 4 h. While TPT-induced H2AX phosphorylation and Chk2 activation were maximal in S-phase cells, Chk2 activation was also much pronounced in G(2)M cells; the least affected by TPT were G(1) cells. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 7 | TPT or MXT induced Chk2 activation occurred at a distinctly slower pace, peaking at 4 h. While TPT-induced H2AX phosphorylation and Chk2 activation were maximal in S-phase cells, Chk2 activation was also much pronounced in G(2)M cells; the least affected by TPT were G(1) cells. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 8 | TPT or MXT induced Chk2 activation occurred at a distinctly slower pace, peaking at 4 h. While TPT-induced H2AX phosphorylation and Chk2 activation were maximal in S-phase cells, Chk2 activation was also much pronounced in G(2)M cells; the least affected by TPT were G(1) cells. | Topotecan | checkpoint kinase 2 | Homo sapiens |
| 9 | TPT or MXT induced Chk2 activation occurred at a distinctly slower pace, peaking at 4 h. While TPT-induced H2AX phosphorylation and Chk2 activation were maximal in S-phase cells, Chk2 activation was also much pronounced in G(2)M cells; the least affected by TPT were G(1) cells. | Topotecan | checkpoint kinase 2 | Homo sapiens |