Title : L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers.

Pub. Date : 2008 Jun

PMID : 18458097






2 Functional Relationships(s)
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1 Recently, the use of L-arginine, the substrate of nitric oxide synthase (nNOS), has been proposed as a pharmacological treatment to attenuate the dystrophic pattern of DMD. Arginine nitric oxide synthase 1, neuronal Mus musculus
2 We show that the inhibitory effect of L-arginine on the NF-kappaB/MMP cascade reduces beta-dystroglycan cleavage and translocates utrophin and nNOS throughout the sarcolemma. Arginine nitric oxide synthase 1, neuronal Mus musculus