Title : TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.

Pub. Date : 2008 Jun

PMID : 18457880






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The inhibitory effect of PTP-PEST was associated with dephosphorylation the Lck kinase at its activation loop site (Y394), reduced early TCR-induced tyrosine phosphorylation, reduced ZAP-70 phosphorylation and inhibition of MAP kinase activation. Tyrosine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens