Title : Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation.

Pub. Date : 2008 Jun 5

PMID : 18449190






1 Functional Relationships(s)
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1 One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4). Lysine H2B clustered histone 21 Homo sapiens