Pub. Date : 2008 Dec
PMID : 18418364
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. | Desipramine | solute carrier family 6 member 2 | Rattus norvegicus | ||
| 2 | The relationship between the ability of repeated desipramine treatment to cause downregulation of the norepinephrine transporter (NET) and produce antidepressant-like effects on behavior was determined. | Desipramine | solute carrier family 6 member 2 | Rattus norvegicus | ||
| 3 | The relationship between the ability of repeated desipramine treatment to cause downregulation of the norepinephrine transporter (NET) and produce antidepressant-like effects on behavior was determined. | Desipramine | solute carrier family 6 member 2 | Rattus norvegicus | ||
| 4 | Treatment of rats with 15 mg/kg per day desipramine reduced NET expression, measured by (3)H-nisoxetine binding and SDS-PAGE/immunoblotting, in cerebral cortex and hippocampus and reduced the time of immobility in the forced-swim test. | Desipramine | solute carrier family 6 member 2 | Rattus norvegicus | ||
| 5 | The present results suggest an important role for NET regulation in the long-term behavioral effects of desipramine and are consistent with clinical data suggesting that enhanced noradrenergic neurotransmission is necessary, but not sufficient, for its antidepressant actions. | Desipramine | solute carrier family 6 member 2 | Rattus norvegicus | ||