Title : Oligosaccharides at each glycosylation site make structure-dependent contributions to biological properties of human tissue plasminogen activator.

Pub. Date : 1991 Sep

PMID : 1840295






3 Functional Relationships(s)
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1 dMM treatment was found to increase both the lysine affinity and catalytic activity of tPA. Lysine chromosome 20 open reading frame 181 Homo sapiens
2 To evaluate the effects of alterations at site 184 and site 448, the catalytic activity and lysine affinity of type I and type II tPA were monitored individually. Lysine chromosome 20 open reading frame 181 Homo sapiens
3 In the dMM-treated sample, type I tPA (with sugars at sites 117, 184 and 448) was found to have 2- to 3-fold increased catalytic activity and an affinity for lysine which was greater than that of type I from untreated preparations, but less than that of control type II tPA (containing sugar only at sites 117 and 448). Lysine chromosome 20 open reading frame 181 Homo sapiens