Pub. Date : 2008 Jun
PMID : 18400024
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MATERIALS AND METHODS: Effect of PBP pre-treatments on 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted skin papillomas was studied in 7,12-dimethylbenz(a)anthracene initiated mice over 40 weeks. | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |
| 2 | MATERIALS AND METHODS: Effect of PBP pre-treatments on 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted skin papillomas was studied in 7,12-dimethylbenz(a)anthracene initiated mice over 40 weeks. | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |
| 3 | Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2). | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |
| 4 | TPA-induced epidermal cell apoptosis was also decreased by pre-treatment with most PBP fractions. | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |
| 5 | Higher levels of p53 and p21 in skin cells pre-treated with PBP fractions followed by TPA treatment as compared to only TPA-treated animals suggested possible activation of a cell cycle checkpoint. | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |
| 6 | In conclusion, the protective effects of PBP fractions could be attributed to inhibition of TPA-induced cellular proliferation. | Tetradecanoylphorbol Acetate | phosphatidylethanolamine binding protein 1 | Mus musculus |