Title : Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis.

Pub. Date : 2008 Jul

PMID : 18398221






5 Functional Relationships(s)
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1 At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide patatin like phospholipase domain containing 8 Homo sapiens
2 At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide patatin like phospholipase domain containing 8 Homo sapiens
3 At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide patatin like phospholipase domain containing 8 Homo sapiens
4 At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide patatin like phospholipase domain containing 8 Homo sapiens
5 Exposure of control cells to a nonlethal concentration of TBHP induced iPLA(2)gamma expression in RPTC. tert-Butylhydroperoxide patatin like phospholipase domain containing 8 Homo sapiens