Title : Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy.

Pub. Date : 2008 Jun

PMID : 18395385






2 Functional Relationships(s)
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1 Simultaneously, the mRNA abundance of transferrin receptor-1 decreased by 80% with age and 48% with HS for young animals, while that of the hepcidin regulator hemojuvelin decreased 37% with age, but increased about 44% with disuse, indicating a dysregulation of iron homeostasis favoring increased intracellular free iron in atrophied muscles. Iron hepcidin antimicrobial peptide Rattus norvegicus
2 Simultaneously, the mRNA abundance of transferrin receptor-1 decreased by 80% with age and 48% with HS for young animals, while that of the hepcidin regulator hemojuvelin decreased 37% with age, but increased about 44% with disuse, indicating a dysregulation of iron homeostasis favoring increased intracellular free iron in atrophied muscles. Iron hepcidin antimicrobial peptide Rattus norvegicus