Pub. Date : 2009 Jan-Feb
PMID : 18393629
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report that ceramide, a bioactive sphingolipid, selectively eliminates hES cells differentially expressing nestin and Tuj1. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 2 | Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 3 | Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 4 | Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 5 | Based on these findings, we conducted long-term studies to determine whether liposomal ceramide can be used to maintain undifferentiated hES cells free of feeder cells. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 6 | We continuously cultured hES cells on matrigel for 4 months with liposomal ceramide in a feeder cell-free system. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 7 | Human ES cells treated with liposomal ceramide maintained their pluripotent state as determined by in vivo and in vitro differentiation studies and contained no chromosomal abnormalities. | Ceramides | ribosome binding protein 1 | Homo sapiens |
| 8 | In conclusion, our findings suggest that exposure to ceramide provides a viable strategy to prevent premature hES cell differentiation and to maintain pluripotent stem cell populations in the absence of feeder cells. | Ceramides | ribosome binding protein 1 | Homo sapiens |