Pub. Date : 2008 May
PMID : 18385943
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | Taken together, our results strongly suggest that H2O2 induces AChE expression via the JNK/AP1/ ATF2 signaling pathway. | Hydrogen Peroxide | acetylcholinesterase (Cartwright blood group) | Homo sapiens |