Title : Inhibition of adipocyte differentiation by phytoestrogen genistein through a potential downregulation of extracellular signal-regulated kinases 1/2 activity.

Pub. Date : 2008 Aug 1

PMID : 18384126






3 Functional Relationships(s)
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1 Genistein dose-dependently decreased the phosphorylation of ERK1/2 in mouse BMSC cultures. Genistein mitogen-activated protein kinase 3 Mus musculus
2 BMSC cultures treated with genistein in the presence of fibroblast growth factor-2 (FGF-2), an activator of the ERK1/2 signaling pathway, expressed normal levels of ERK1/2 activity, and, in so doing, are capable of undergoing adipogenesis. Genistein mitogen-activated protein kinase 3 Mus musculus
3 BMSC cultures treated with genistein in the presence of fibroblast growth factor-2 (FGF-2), an activator of the ERK1/2 signaling pathway, expressed normal levels of ERK1/2 activity, and, in so doing, are capable of undergoing adipogenesis. Genistein mitogen-activated protein kinase 3 Mus musculus