Pub. Date : 2008 Apr 1
PMID : 18381438
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, the induction of apoptosis was 5-fold greater in the p53+/+ cells compared with the p53-/- cells. | Irinotecan | tumor protein p53 | Homo sapiens |
2 | With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, the induction of apoptosis was 5-fold greater in the p53+/+ cells compared with the p53-/- cells. | Irinotecan | tumor protein p53 | Homo sapiens |
3 | With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, the induction of apoptosis was 5-fold greater in the p53+/+ cells compared with the p53-/- cells. | Irinotecan | tumor protein p53 | Homo sapiens |
4 | With the combination therapy of SN-38 (the active metabolite of CPT-11) followed by flavopiridol, the induction of apoptosis was 5-fold greater in the p53+/+ cells compared with the p53-/- cells. | Irinotecan | tumor protein p53 | Homo sapiens |
5 | Depletion of Rad51 by small interfering RNA (siRNA) sensitized both p53+/+ and p53-/- cells to SN-38-induced apoptosis with increase of gamma H2AX, a marker of DNA damage. | Irinotecan | tumor protein p53 | Homo sapiens |